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Monday, April 30, 2012
Thursday, April 5, 2012
Why Is Email Marketing Very Important To Your Online Business ...
Email Marketing
Fundamentals about email marketing software comparison, email marketing, email marketing manager and free email marketing lists
Email marketing is a very popular method of advertising services and products. Use these tips to have the utmost achievement with your email marketing advertising campaign. They exist at a fast pace and expect services and products to match this particular pace.
Numerous email marketing campaigns have failed because the internet marketer sends his list of subscribers too many sales pitch. Give a link to a previous newsletter or two, or links to a few teaser bits of content. Go and use them right now and watch the way your sales and profits improve.
The general guideline is to display your subscription above the fold of the website. Now you simply use it straight into your email autoresponder, which has a thanks page with regard to subscribing. People love free stuff, which is a good method to create devotion and show that you?re not only a mean selling machine.
Email marketing has confirmed over and over to become a great method to get in touch with new as well as existing clients to be able to build or renew your romantic relationship with them. Email marketing for ski hotels delivers the information straight to the customer most likely to consider advantage of the actual offers as well as invitations marketed. Depending on what you market, you could probably take things light and unwind for most of the week.
If you are doing it right, money will come in a short period of time simply by sending an email. If you have a list of Ten,000 e-mail subscribers, you are virtually certain to get visitors to your website on a daily basis. Announces regarding events, special offers, products etc through high quality email content.
If you room the emails Three days apart, you?ve 2 months worth of emails that you can let operate automatically. Does the content of your email somehow provide value, or could it be ?all about me personally?? (your company.) You must constantly put yourself in the positioning of your email recipients as well as think about an amount convince these to open as well as act on your email. You may also automatically re-send your original e-mail message to your customer?s brand new address, so this whole process can happen within close to real-time without you lifting the finger.
Such a medium may have been unimaginable a generation ago, but email marketing may be the present along with the future. In this manner the company or individual builds their list of potential prospects responsibly, avoiding allegations associated with unsolicited commercial emails (UCE), more commonly known as spam. However beware it must be a valued giveaway not some low quality, rubbish material otherwise you will get slapped very hard by people joining your list and then immediately unsubscribing because it?s poor quality ? and that my friends means probably they?ll not come back.
Produce a database of regular customers (Buddies of the Cafe) who are rewarded for placing early orders. Virtual figures are extremely efficient for offline email purchase campaigns because they provide a simple, familiar method for people to submit their current email address. However, you have to put in some thoughts for your subject heading as it is important for you to be as practical as possible.
You must have a communication information that is of interest and relevance for your customer. It?s therefore important for you to definitely learn how to neat thing from your email marketing campaigns without abusing this wonderful marketing tool. What you say, so when you say it is extremely essential.
So some months you may get Three sales for every 100 brand new subscribers, plus some months you may get 3 sales for every Three hundred new customers.
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Franchising Career Coaching Enterprise ? Enjoy Benefits Galore ...
Starting a franchise in career coaching is the right thing to do for a person with experience in career coaching. This is a lucrative field and is attracting more and more people. Starting a franchise in career coaching is considered as a wise business move. How do you define a career coach? He is some-one who tries to help people with their careers, that is he helps them to start a meaningful career or to change tracks from one field to another. The work also includes helping the clients with their retirement, layoff, job termination or a change in career. Whenever an individual shifts his career or wants proper career counseling and guidance, they usually turn towards a franchise in career coaching for advice. An individual, not part of a career coaching enterprise can also perform the function of a career coach.
Franchising of a business is an important step for anyone wishing to start a reputable business. According to the statistics offered by the U.S State Department of Commerce 62% of all business that are not franchised close down within a period of six years. The reason for the failure of these non-franchised businesses and the success of their franchised counterparts is due to the fact that franchised businesses have a wide network of products and support to aid them. Therefore any individual wanting to start a successful career coaching enterprise would be well advised to franchise it. The process of franchising comes with a fee that is on the higher side; therefore most individuals avoid it not knowing that the benefits that are obtained by them far out-weigh the money spent in franchising it.
The best way to jump start a career as a career coach is to start a franchise in career coaching. This would ensure their success. Most individuals do not make proper sense of a franchise, usually associating it with big business like burger king. The concept here is the same for different businesses. Franchising of a business gives a company the right to market or sell specified services and products of the business under a brand name, which can be used in marketing strategies and advertisements. Agreements are drawn between all respective parties to make it profitable for everyone involved.
A franchiser provides for the support and services needed to get the business up and running getting royalties in return. The franchiser make sure that a new business makes it big, as it is profitable to him in accordance to the old adage ? you scratch my back, I scratch yours?.
Abhishek is a Career Counselor and he has got some great Career Planning Secrets up his sleeves! Download his FREE 71 Pages Ebook, ?Career Planning Made Easy!? from his website http://www.Career-Guru.com/769/index.htm. Only limited Free Copies available.
Author: Abhishek Agarwal
:
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Community-onset Clostridium difficile linked to higher risk of surgery
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uk3MN1qEHPyw3vrBQ7bECqyDUIhs6pDwx2ys4bgJ55P3vuJ0j5Y2nsXsuRVp3fZ-dpeUWZeLBBRLAt2sK7CalNKk-VkVjxRI3tlATEiJA=s0-d){kind=small}
Public release date: 4-Apr-2012[ | E-mail |
Share ] Contact: Shannon Murphy
smurphy@gymr.com
202-745-5066
Society for Healthcare Epidemiology of America
Chicago, IL (April 4, 2012) -- Patients whose symptoms of Clostridium difficile infection (CDI) start outside of the hospital setting have a higher risk of colectomy due to severe infection, according to a large multicenter study funded by the Centers for Disease Control and Prevention (CDC) and published in Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.
Infection from C. difficile is associated with antibiotic use and results in colitis and diarrhea. Severe cases can be life-threatening. Colectomy, or surgical removal of most or all of the large intestine, is the treatment of choice for patients who have life-threatening CDI that does not respond to medical therapy. However, it is associated with a high risk of death in these very sick patients.
To assess rates of colectomy due to CDI, a team of researchers at 5 tertiary-care hospitals in the US collected data on CDI cases over a six year period from 2000 and 2006. They identified 8,569 cases of CDI, and 75 patients of this group underwent a colectomy due to severe CDI, a rate of 8.7 colectomies per 1000 CDI cases. Patients with community-onset CDI had colectomy rates four times higher than patients who developed symptoms while hospitalized. Individuals who were 65 years old or older were also more likely to have a CDI-related colectomy.
Patients in the community were previously considered to be at low risk for CDI. A recent CDC Vital Signs reported that 75 percent of CDI symptoms first show in community settings like nursing home patients or in people recently cared for in doctor's offices and clinics. Together these findings illustrate the increasing trend and severity of community-onset CDI.
Future prospective surveillance studies using standardize case definitions are needed to better characterize severe complications from CDI and to help healthcare providers decide which patients would potentially benefit from surgical intervention.
###
Amelia M. Kasper, Humaa A. Nyazee, Deborah S. Yokoe, Jeanmarie Mayer, Julie E. Mangino, Yosef M. Khan, Bala Hota, Victoria J. Fraser, Erik R. Dubberke, "A Multicenter Study of Clostridium difficile InfectionRelated Colectomy, 2000-2006." Infection Control and Hospital Epidemiology 33:5 (May 2012).
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 15 out of 140 journals in its discipline in the latest Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings www.shea-online.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 4-Apr-2012[ | E-mail |
Share ] Contact: Shannon Murphy
smurphy@gymr.com
202-745-5066
Society for Healthcare Epidemiology of America
Chicago, IL (April 4, 2012) -- Patients whose symptoms of Clostridium difficile infection (CDI) start outside of the hospital setting have a higher risk of colectomy due to severe infection, according to a large multicenter study funded by the Centers for Disease Control and Prevention (CDC) and published in Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.
Infection from C. difficile is associated with antibiotic use and results in colitis and diarrhea. Severe cases can be life-threatening. Colectomy, or surgical removal of most or all of the large intestine, is the treatment of choice for patients who have life-threatening CDI that does not respond to medical therapy. However, it is associated with a high risk of death in these very sick patients.
To assess rates of colectomy due to CDI, a team of researchers at 5 tertiary-care hospitals in the US collected data on CDI cases over a six year period from 2000 and 2006. They identified 8,569 cases of CDI, and 75 patients of this group underwent a colectomy due to severe CDI, a rate of 8.7 colectomies per 1000 CDI cases. Patients with community-onset CDI had colectomy rates four times higher than patients who developed symptoms while hospitalized. Individuals who were 65 years old or older were also more likely to have a CDI-related colectomy.
Patients in the community were previously considered to be at low risk for CDI. A recent CDC Vital Signs reported that 75 percent of CDI symptoms first show in community settings like nursing home patients or in people recently cared for in doctor's offices and clinics. Together these findings illustrate the increasing trend and severity of community-onset CDI.
Future prospective surveillance studies using standardize case definitions are needed to better characterize severe complications from CDI and to help healthcare providers decide which patients would potentially benefit from surgical intervention.
###
Amelia M. Kasper, Humaa A. Nyazee, Deborah S. Yokoe, Jeanmarie Mayer, Julie E. Mangino, Yosef M. Khan, Bala Hota, Victoria J. Fraser, Erik R. Dubberke, "A Multicenter Study of Clostridium difficile InfectionRelated Colectomy, 2000-2006." Infection Control and Hospital Epidemiology 33:5 (May 2012).
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 15 out of 140 journals in its discipline in the latest Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings www.shea-online.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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ONLINE SHOPPING FOR KINDLE E-BOOKS | Best Seller Valentine ...
[unable to retrieve full-text content]Best Seller Valentine Gift Card 2012. Welcome to goalsome.com .... Compare 8 kindle - eBook Readers and PDAs ... ratings and product reviews are written and submitted by online shoppers to assist you as you shop.
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Wednesday, April 4, 2012
Why Should really You Put Money Into Silver And Not Gold? | forexa ...
You Are Here: Home ? Investing & Trading ? Why Should really You Put Money Into Silver And Not Gold?
The top economies of the planet separated the gold and silver price tag index from the worth from the paper currency a lengthy time ago. The paper currency can be a fiat currency in that it is actually supported by the governments coming together and issuing an official decree, that is all. History is witness for the truth that none of the fiat currencies with the past have stood the test of time and economic trials and tribulations. All currencies have perished as well as the knowledgeable monetary pundits look in the US dollar with trepidation and fear.
The investors are seeking to allocate at the very least 25% of their economic portfolio to purchasing gold and silver. Why is the investor investing in gold and silver coins? For the reason that probably the most strident critics in the US monetary policies feel that the globe economy is going to become pushed back towards the barter method of exchange and trade.
When you consider hard adequate you are going to realize that there?s nothing readily available aside from the silver reserves of this planet to enable the barter method to take root and flourish. Do you comprehend that, in such a scenario, silver could be the exchange medium that may be simply traded for purchasing food and necessary day-to-day provisions?
Silver is available in the form of coins ranging from 1 ounce to 5000 ounces in weight. This feature alone lends itself to a viable exchange medium for traders and their buyers.
So, now you might understand that investing in silver ingots and coins tends to make a great deal far more sense than the insanely high priced gold or platinum and how much gold do you assume is offered to get a equivalent use? Even if all of the gold in the world is re-distributed amongst the 7 billion population of this world every single person will hold less than 25$ worth of gold.
Also, if you see the ratio of growth of gold vs silver, silver is growing much faster and in a few years, if not months, one may actually see a drop in gold prices as investors rush to invest in the rapidly growing silver.
The method of re-printing paper currency to tide over financial deficits has additional debased the US dollar. The Euro which was launched amid considerably fan fare is currently floundering. The intelligent investors are turning away and investing in valuable metal and gold could be the valuable metal which was most desirable.
But if you study the economic scenario it will not be hard to understand that the investors were running after the wrong metal. Silver is the metal which has seen unprecedented demand from across the industrial sectors like solar energy, electronics and electricity, health care, chemicals?etc.
The demand for silver is expanding quickly where as the production and provide is meager. What ever consumption of silver that is certainly taking location within the industrial sector is irretrievable. The retrieval approach is quite expensive and hence not viable.
The fact is that Chinese investors are increasing their silver purchases and so are the investors from India, and these are the strongly growing conservative economies using the biggest as well as the youngest human resources available.
Less than a decade ago an ounce of silver was available for 5$. In 2011 silver rapidly rose to 50$ an ounce. Then there was a correction and now the metal is trading at around 34$ an ounce. The market indications are that in the next 12 months or so, silver is going to appreciate dramatically and even at 100$ an ounce it is going to be a profitable deal as investment pundits predict that silver may well touch 200$ an ounce.
So If you are investing in gold and silver coins you understand that you are investing for a bleak future that can only be off set by the metal reserves you hold, preferably silver.
Any investment can be tricky, but gold in today?s market can be frightening. I strongly suggest you find a guide with experience when investing in either gold or silver .
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Tuesday, April 3, 2012
Large tornadoes, damage reported in Dallas area
Destroyed vehicles sit in a Kenworth trailer lot after a tornado that swept through the area toppling many of the trailers on the lot Tuesday, April 3, 2012, in Lancaster, Texas. Tornadoes tore through the Dallas area Tuesday, peeling roofs off homes, tossing big-rig trucks into the air and leaving flattened tractor trailers strewn along highways and parking lots. (AP Photo/Tony Gutierrez)
Destroyed vehicles sit in a Kenworth trailer lot after a tornado that swept through the area toppling many of the trailers on the lot Tuesday, April 3, 2012, in Lancaster, Texas. Tornadoes tore through the Dallas area Tuesday, peeling roofs off homes, tossing big-rig trucks into the air and leaving flattened tractor trailers strewn along highways and parking lots. (AP Photo/Tony Gutierrez)
Harold Widner clears a fallen tree from his truck in Arlington, Texas on Tuesday, April 3, 2012. Several reported tornadoes tore through the Dallas area on Tuesday, tossing semis in the air and leaving crumpled tractor trailers strewn along highways and in truck stop parking lots. ?The National Weather Service reported at least two separate "large and extremely dangerous" tornadoes south of Dallas and Fort Worth. (AP Photo/The Fort Worth Star-Telegram, Ron Jenkins) MAGS OUT (REV-SHARE)
Ten year-old Ty Proctor surveys damage after a tornado struck Arlington, Texas on Tuesday, April 3, 2012. Several reported tornadoes tore through the Dallas area on Tuesday, tossing semis in the air and leaving crumpled tractor trailers strewn along highways and in truck stop parking lots. ?The National Weather Service reported at least two separate "large and extremely dangerous" tornadoes south of Dallas and Fort Worth. (AP Photo/The Fort Worth Star-Telegram, Ron Jenkins) MAGS OUT
Debris scatter the street in southern Dallas County, Texas on Tuesday, April 3, 2012. Arlington, Texas on Tuesday, April 3, 2012. Several reported tornadoes tore through the Dallas area on Tuesday, tossing semis in the air and leaving crumpled tractor trailers strewn along highways and in truck stop parking lots. ?The National Weather Service reported at least two separate "large and extremely dangerous" tornadoes south of Dallas and Fort Worth. (AP Photo/The Fort Worth Star-Telegram, Ron Ennis) MAGS OUT (REV-SHARE)
A man walks beneath the trailer of an 18-wheeler that sits atop a tree and a power line pole after a tornado swept through the area Tuesday, April 3, 2012, in Lancaster, Texas. Tornadoes tore through the Dallas area Tuesday, peeling roofs off homes, tossing big-rig trucks into the air and leaving flattened tractor trailers strewn along highways and parking lots. (AP Photo/Tony Gutierrez)
DALLAS (AP) ? Tornadoes tore through the Dallas area Tuesday, peeling roofs off homes, tossing big-rig trucks into the air and leaving flattened tractor trailers strewn along highways and parking lots.
The National Weather Service confirmed at least two separate "large and extremely dangerous" tornadoes. Several other developing twisters were reported as a band of violent storms crept through the metropolitan area, destroying mobile homes and forcing hundreds of flight cancellations at Dallas-Fort Worth International Airport.
There were no immediate reports of injuries.
"The officers were watching the tornadoes form and drop," said Kennedale police Chief Tommy Williams. "It was pretty active for a while."
Highway video cameras showed a large, dark funnel cloud moving on the ground not far from a busy Dallas interstate early Tuesday afternoon. Big-rig tractor trailers crumpled like soda cans littered an industrial parking lot, and flattened trailers clogged the sides of highways and access roads.
In Lancaster, south of Dallas, television helicopters panned over exposed homes without roofs and flattened buildings. Broken sheets of plywood blanketed lawns and covered rooftops. Residents could be seen walking down the street with firefighters and peering into homes, looking at the damage after the storm passed.
Devlin Norwood said he was at his Lancaster home when he heard the storm sirens. He said he made a quick trip to a nearby store when he saw the funnel-shaped tornado lower, kick up debris and head toward his neighborhood.
"I didn't see any damage until I got back home. We had trees destroyed, fences down, boards down, boards penetrating the roof and the house, shingles damaged," said Norwood, 50, an accountant and graduate student.
The storm pushed cars into fences and toppled trees. Branches and limbs scattered across lawns and residential streets, and in one driveway, a tow-behind RV was left torn apart and crumpled.
"Obviously we're going to have a lot of assessments to make when this is done," Dallas County spokeswoman Maria Arita said.
Dallas Police spokeswoman Sherri Jeffrey said an apparent twister also touched down and caused damage within the city's southern limits, though the extent was not immediately known.
American Airlines canceled nearly all its departures from its hub at DFW on Tuesday evening and diverted others to different airports. Spokeswoman Andrea Huguely said the airline also was pulling dozens of planes out of service to inspect them for hail damage.
DFW spokesman David Magana said there were no reports of damage to the airport itself. Magana said employees pulled passengers in the terminals away from glass windows during the storms and directed them to stairwells, stores and restaurants in the inside area of the airport.
Flights also were canceled at Dallas Love Field, which is a big base for Southwest Airlines. That airline canceled more than 45 flights in and out of the airport by Tuesday evening.
____
Associated Press writers Terry Wallace and David Koenig in Dallas and Betsy Blaney in Lubbock contributed to this report.
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Why I Wasted My Vote on Jon Huntsman
Ah, but I?ve figured out how to make politicians pay attention to me. Since 2007, I?ve been a registered Republican in Washington, D.C. There are not very many of us. The last time the primary came here, in a city of 617,966, only 6,211 of us turned out to vote. How many Democrats turned out? Only 20 times as many: 123,994 of them. Us lucky Republican voters got to be statistically significant. All they got was the 44th president.
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Monday, April 2, 2012
Insight: Chasing cheaper cancer drugs
LONDON (Reuters) - In a nondescript suburb south of London, tucked away behind a big hospital, Paul Workman and fellow scientists are celebrating victory in the "World Cup" of cancer drug research for their work in discovering a stream of new medicines.
But the win is bitter-sweet. One of the new drugs behind the coveted prize from the American Association for Cancer Research (AACR) has been deemed too costly to use in state-run British hospitals like the one next door.
It is a stark example of the pricing crisis now facing cancer medicines across the globe.
In developed and developing countries alike, patients and governments are struggling to pay for modern drugs that are revolutionizing cancer care but may cost tens of thousands of dollars a year for each patient.
"It's very frustrating," says Workman, who heads up the drug discovery unit at the Institute of Cancer Research (ICR), which is funded in large part by charities.
What is needed, he believes, is a new model that takes advantage of the highly specific nature of modern targeted therapies to slash drug development timelines and costs.
In the long term, Workman is convinced that will happen. But for the moment the world is caught in a pinch point as global drug companies put sky-high price tags on cancer medicines in a bid to recoup development costs for drugs aimed at a relatively small number of cancer sufferers.
The strains are growing - whether in Europe, where austerity has savaged healthcare budgets, or in the United States, where out-of-pocket costs can bankrupt patients, or in the developing world, where price tags of around $5,000 for a month's drug supply are simply out of reach.
INDIA LOSES PATIENCE
India, a country with a long history of making cheap off-patent drugs and a sometimes brittle relationship with Western drugmakers, has finally lost patience.
New Delhi shocked the global drugs industry in March by effectively ending Bayer's monopoly on kidney and liver cancer drug Nexavar and issuing its first-ever compulsory license, allowing local generic firm Natco Pharma to produce and sell the drug cheaply in India.
In a move to head off the same threat to its patented drugs, Roche, the world's biggest maker of cancer medicines, plans to offer significantly cheaper locally branded versions of two other cancer treatments, Herceptin and MabThera, under an alliance with Emcure Pharmaceuticals.
Further showdowns with Big Pharma seem inevitable. Novartis, for example, is challenging a decision not to grant a patent for its leukemia drug Glivec in a case that will go to the Indian Supreme Court on July 10.
Michelle Childs, head of policy at Medecins Sans Frontieres and a critic of many industry practices, says the approach taken by Big Pharma to date of excluding the vast majority of people living in developing countries - barring a small but growing middle class - is not sustainable.
She expects powerful countries like India and China, both of which have capacity to make cheap generic drugs, to flex their muscles more in future as the battle over access to medicines enters a new phase.
"Traditionally, the focus has been on drugs for infectious diseases like HIV and tuberculosis, but increasingly developing countries are facing a double burden of disease as we see the rise of chronic diseases like cancer and diabetes," she says.
The issue is not confined to poorer countries - as Workman at the ICR knows all too well.
His team spent many years working on a novel prostate cancer pill that won special recognition in the citation for the AACR prize awarded in Chicago on Sunday (April 1), only to find that Britain's National Institute for Health and Clinical Excellence (NICE) considers it too costly to be used.
If the cost-effectiveness watchdog does not change its mind, Zytiga, which is marketed by Johnson & Johnson and costs 2,930 pounds ($4,700) for a month's supply, will be off-limits for Britons on standard state healthcare.
Significantly, NICE also thinks Bayer's Nexavar is too expensive - highlighting the common concerns about costs shared by healthcare authorities in different parts of the globe.
Such tough calls are inevitable when budgets are limited, according to NICE chairman Mike Rawlins, who says it is time to challenge drug companies about the high prices they seek for products that sometimes offer only modest benefits.
$85 BLN SALES BY 2016
The debate over how to price cancer medicines matters intensely for the pharmaceuticals industry and society at large.
Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths in 2008 and predicted to top 13 million in 2030, according to the World Health Organisation. Some 70 percent of deaths occur in low- and middle-income countries.
For drugmakers, the disease is a rich seam of sales and profits. Cancer medicines overtook cholesterol fighters as the biggest-selling selling prescription drug class five years ago and sales are set to hit $85 billion in 2016, up from $58 billion last year and a mere $8 billion in 2000, according to consensus forecasts compiled by Thomson Reuters Pharma.
Cancer is particularly attractive commercially as patents expire and profits wane on drugs in other areas.
Privately, though, even some drug company executives wonder if the industry will be charging such high prices in a few years time.
The price tags on a flurry of new entrants have certainly pushed the envelope, with Bristol-Myers Squibb's melanoma treatment Yervoy costing $120,000 for a four-infusion course and Dendreon's Provenge for prostate cancer priced at $93,000 for a three-dose course.
In the United States, some cancer patients have abandoned medical care because of their bills or else face a significant risk of bankruptcy, according to studies presented at the American Society of Clinical Oncology last year.
Europe's more socialized healthcare system creates different strains. Cash-strapped governments have slashed drug prices, racked up close to $20 billion in unpaid bills for treatments and, crucially, are becoming increasingly reluctant to pay for innovative new drugs.
Andrew Witty, chief executive of GlaxoSmithKline, says European governments are making a false economy by delaying the introduction and reimbursement of promising new treatments, especially for cancer, in their short-term drive to save money.
Pfizer CEO Ian Read told Reuters last month there was a serious "disconnect" between the marketplace in Europe and the desire of governments to sustain a vibrant research base. "Europe is not paying its fair share of innovation," Read said.
SMALLER, SMARTER TRIALS
From his office at the ICR behind the Marsden hospital in Sutton, Workman has an unusual vantage point across the cancer landscape. With a staff of 160, his team is as large as the oncology departments of some Big Pharma companies and in the past six years has discovered 16 innovative cancer drugs.
Thanks to rapid advances in genetics, scientists now have a fundamental understanding of the workings of tumor cells that did not exist in the days when toxic chemotherapy was the only tool in the medicine chest.
However, the lion's share of the $1 billion or more it takes to bring a new drug to market is not chewed up by scientists working in the lab but by the cost of running clinical trials. It is the high failure rate of these studies that pushes up the price of those few drugs that do succeed.
Still, there is light at the end of the tunnel. The ability to target modern cancer treatments to the genetic profile of individual patients means trials can now be designed with far fewer patients, reducing costs dramatically.
Workman predicts that in five years the average success rate for a cancer drug starting out in early-stage clinical development will be 50 percent, up from 5 percent now.
"It is no longer a lottery," he says.
"Trials in future will be smaller, quicker and cheaper. The failure rate will go down and the economic model will rebalance. That means the R&D costs that companies need to recoup when they sell a new drug will come down and those savings should be passed on to the patients."
There are already encouraging signs. Roche's new melanoma drug Zelboraf, for example, which is designed for patients with one type of abnormal gene, was approved in 2011 less than five years after the start of its first clinical trials - far shorter than the timescale for most drugs.
Even so, modern cancer drugs are never likely to be affordable to the poor of Asia, Africa and Latin America under the current patent-protected system - one reason why MSF's Childs says governments need to investigate new models for rewarding innovation, possibly via a system of upfront payments.
Back at the ICR, Workman's colleague Johann de Bono, who led much of the clinical research on Zytiga, says it is clear something in the current system has to give:
"I'm a Christian, so human life to me is very valuable. But how do you value a human life? It's very difficult." ($1 = 0.6285 British pounds)
(editing by Janet McBride)
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Ceton's Q DVR companion app for Windows Phone gets detailed tour (video)
You might recall Ceton's Q DVR making its debut at the start of the year and now the beans have been spilled on the multiroom recorder's companion app. The Windows Phone 7 version separates out into home, television and recent screens. The home section houses galleries and search, while television will display scheduled recordings, channel guides and management options for those upcoming shows. Finally, the recent screen keeps tabs on what you've been watching or recording last, all done in that inimitable metro style. There's no launch date yet, but Android and iOS versions are also being readied for release. You can take a video tour of the features right after the break.
Continue reading Ceton's Q DVR companion app for Windows Phone gets detailed tour (video)
Ceton's Q DVR companion app for Windows Phone gets detailed tour (video) originally appeared on Engadget on Mon, 02 Apr 2012 09:53:00 EDT. Please see our terms for use of feeds.
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High Rock Themes ? Who Is Investing in Gold? Be Smart plus Be ...
In times of political and economic instability, countless people are in search for the best investment strategy and financial solution that guarantees the biggest gain. There are a lot of options to choose from in terms of investment solutions; several invest their in property, inventory and mutual funds, though people merely choose to get their in specialized brokers that does all the suit them. But there are those that invest in gold. Why is gold so important? And that buying gold?
Preparing for Economic Downfalls
Gold is recommended because a kind of investment that is value creating due to its countless features. This precious metal is so rare because it cannot manufactured and may merely be found. Its colour is connected with money and is virtually not susceptible to decay, creating it seemingly indestructible. This really is the key feature of gold creating it quite valuable since almost all of the ingredients about earth perish.
Gold is revenue and is even better than paper revenue since its value is not affected by the numerous changes that happen within an economy. Gold will constantly be recognised as a trading instrument. Let us take a consider a few of the benefits of buying gold.
Investing in gold is an alternate as well as a viable solution to inventory markets. Investing on it is a more secure choice instead of buying the inventory market. Although buying gold is not recommended if the goal is to have a short timeframe gain, for it happens to be more of a prolonged expression financial instrument. During times of crisis period, where inventory markets are down, the gold price goes up. When this complicated period is over, the inventory market goes back upwards, when the cost of a gold bar continues to be stable.
The Precious Metal as well as its Diverse Forms
One of the types where gold can be purchased is in coin. Coin collectors are those that invest in gold money for different reasons. These include either curious with all the amount of gold that the coin consists or those that gather them due to its famous value. For others that are deprived of the time to look for these valuable metals but have the revenue, buying gold pubs makes the work easier since they are simpler to transport and shop.
They come in different shapes and sizes as well as the expense of the gold bar is quoted depending about its purity and other aspects. There are different kinds of investors of gold. Collectors are one with them. Gold is commonly employed in different types of jewellery. Because of that, two thirds of the gold accessible internationally is in the jewellery business.
how to invest in gold directly can be achieved by buying authentic gold bullion or from other means like share derivatives, buying gold certificates and accounts. Gold is viewed as a limited and stable asset and individuals frequently take advantage of it in times of economic and financial crisis. A person that is buying gold gains big earnings over the long haul. Gold is money in earlier times and up to today and may surely hold its value and value in the actual. Thus, gold is considered a winning investment considering no matter how erratic the movement of the economy is, its value would not decrease. Truth be told, the worth of gold increases over a period of time. The more gold you invest in today, the more protection you earn for the actual. Buying gold is a wise position of your revenue. Hence, this enlightening instrument may help save you incredibly in times of crisis.
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Sunday, April 1, 2012
Creepy Girls Around Me app exposes Facebook privacy concerns
Girls Around Me, an app that up until just recently displayed foursquare check-in information of women within a user?s proximity, illustrates how privacy increasingly takes a backseat to social connectivity.
The app is blatant about its purpose right within its Developer?s Notes.
This foursquare-based tool helps you SEE WHERE NEARBY GIRLS ARE CHECKING IN, and shows you what they look like and how to get in touch! You can also search for guys or see who?s hanging out at a particular place.
The app is so easy to use: search for girls or guys, browse the map and press scan to begin scanning the area for recent check-ins! See where people are spending this evening. Look at the photo and decide whether to seek out someone new at a nearby venue or play it cool by showing your interest via Facebook!
The app, which was developed by Russia-based SMS Services O.o.o., basically lets guys prey upon women who don?t restrict their privacy settings on Facebook. While it is incumbent upon all users to understand the tradeoff between privacy and connectivity, one wonders how this app was allowed into the App Store in the first place.
Credit The Cult of Mac for bringing this issue to everyone?s attention.
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Nir Rheumadiagnostik ? The strength of Detox: Tips on how to ...
If you do not stay in the heart of the particular forest, a person breathe in simply pure air, feed on simply natural food items when you find yourself eager; and therefore those people food items supply the actual natural requirements of buikspier oefeningenyour physique; you certainly not encounter any sort of worry, worry as well as panic and you just activity daily? chances are that you must detoxing.
Similar to the particles and also crud this increases in the house demands once a year house-cleaning ? ?toxins?, extra pounds and also Goodness understands what precisely accumulate within your body.
We all need to try and do an ordinary house-cleaning ? and therefore suggests letting your system an opportunity to cure alone, launch extra pounds, launch their waste, and acquire a different brand new begin.
Your whole body comes with an wonderful self-healing system crafted directly in it all, but in sequence to permit it all get the job done, you should give it the others it takes.
For this reason starting a fast is a huge tradition part of quite a few global made use of, and also nearly every option health and fitness exercise endorses getting some sort of starting a fast as well as ?detox kuurdiet?.
Just what Detox Eating habits?
The ?detox diet? is not about attending a repair facility to get drug use. The idea of ?detox? has been used during natural bags in the sense of ?removing waste.? The detoxing diet regime will allow your system to clean alone of accumulated waste, worry, so helping it all launch unwanted fat and also pounds.
The detoxing meals are a fixed diet regime you comply with, often mixed with a fitness system, stay or even a couple of weeks (or simply for a longer period). It is really type of just like starting a fast, but it?s simpler to perform and you can now practice it in your own home when it?s needed.
Indications You?ll want to Detox
Always be in a position toafval tips recognize on your own when you wish to take a some sort of detoxing diet regime. If you want for on your own in the hand mirror and don?t just like what you see, you may not such as the extra pounds you have been carrying all around? after that detoxing diet regime will allow you to get back on course using a nutritious diet and also launch extra unwanted fat..
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Mega Millions: Will lotteries and other gambling move to the Internet?
In December, the?US Department of Justice?announced that it was reversing its position that all Internet gambling was illegal, clearing the way for a potential boom in online gambling.?
For the millions of Americans who bought Mega Millions lottery tickets, the waiting is over.
Skip to next paragraphThe vast majority lost, as they knew they would in a gamble with mega-long odds (176 million to one). A handful won. The names of those whose tickets matched the ten winning numbers haven?t been announced yet, but state officials in Kansas, Illinois, and Maryland say winning tickets were sold there.
They?ll split what?s left of the $640 million jackpot (combined from 42 state lotteries) after Uncle Sam and state taxing authorities claim their share. Others whose $1 ticket matched some of the winning numbers could be paid lesser amounts ranging from $2 to $250,000 (where the odds still were 4 million to one).
States are the biggest winners. Lottery ticket buyers spent some $1.5 billion, most of which goes into state coffers.
The Monitor's View:?The odds and ends of Mega Millions jackpot lottery
Forty-three states now have lotteries, and some gambling advocates are pushing to legalize online lotteries and other forms of Internet gambling.
In December, the?US Department of Justice?announced that it was reversing its position that all Internet gambling was illegal, clearing the way for a potential boom in online gambling.?
States would have to approve such steps. At this point, only Nevada allows online poker there and the District of Columbia is moving in that direction as well. Minnesota has an online lottery. Other states are considering forms of online gambling ? which is practiced illegally via offshore and underground Internet sites.
Some experts warn that legalizing online gambling more broadly would increase the number of problem gamblers.
"If it's legalized, that would put electronic gambling ? the crack cocaine of gambling addiction ? on every work desk, [in] every living room, [on] every mobile phone," John Kindt, a professor of business and legal policy at the?University of Illinois at Urbana-Champaign?and a senior editor of the US International Gambling Report, told Monitor correspondent Husna Haq.
"It's just bad social and economic policy," he said. "It's going to expand the social ills and taxpayer costs of addicted gambling and problem gambling. Desperate states will be getting in new lottery revenues at the expense of creating new addicted gamblers and problem gamblers."
Two million adults in the US are estimated to meet criteria for pathological gambling in a given year, according to the National Council on Problem Gambling (NCPG).
Another 4-6 million would be considered problem gamblers, reports NCPG. That is, they do not meet the full diagnostic criteria for pathological gambling, but meet one of more of the criteria and are experiencing problems due to their gambling behavior.
Some three percent of Americans are problem gamblers, according to other estimates, a figure that?s higher for teenagers and college students.
Experts on gambling addiction warn that expanding online betting could make the problem worse.
?Online gambling websites are among the fastest growing and most profitable businesses in existence today,? according to the TechAddiction Information and Treatment Service in Nova Scotia, Canada. ?Compared to traditional land-based casinos, online gambling websites are able to operate at a fraction of the cost, do not require tangible materials or equipment (machines, tables, security cameras, a physical building, etc.), and do not need the hundreds of staff that would normally be required for a traditional casino.?
Meanwhile, millions of Americans continue to buy lottery tickets, dreaming of the next Mega Millions event.
The Monitor's View:?The odds and ends of Mega Millions jackpot lottery
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Ultra-endurance, survival fitness, mental health and business - A ...
In just over 18 months time I'll be turning 40, which is not something I'm terribly looking forward to, but I want to approach it in the right frame of mind - and body.
I've known for a long time that I need to have more self-control and stick to things that I say I'm going to do, so here are a few things I would like before the big 4-0 comes along:
- Be fit enough to undertake an ultra-endurance event such as an ultra-marathon or century bike ride.
- Have mastered a few of the survival skills I've mentioned a few times.
- Be self-employed.
I know that may seem like a lot to aim for, but with small steps it may well be within reach, if not by my 40th birthday then certainly within my early 40s.
And here's how I intend to do it:
- Small steps, like I said. Take things one step at a time but try to ensure I'm always making progress.
- Monitor my progress. This is where I've let myself down in the past. I'm aiming to record progress (here) at least five times a week, possibly with a weekly round-up.
- Re-evaluate every three months. See where I'm going and what I could change, if anything.
And, no, this is not an April Fool's joke...
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